4-[4-[(5S) -5-(Aminomethyl) -2-oxo-3-oxazolidinyl] phenyl] -3-morpholinone Hydrochloride

12.Matsakaicin 4- (4-aminophenyl) -3-morpholinone (1) na anticoagulant rivaroxaban an shirya shi ta hanyoyi guda biyu: ①Bromobenzene an yi nasara tare da ethanolamine da chloroacetyl chloride don samun 4-benzene. 1, kuma jimlar yawan amfanin ƙasa shine kusan 32%;②An fara nitrated Bromobenzene, sannan a mayar da martani da ethanolamine don samun 2- (4-nitroanilino) ethanol, wanda chloroacetyl chloride ya rufe.Sakamakon raguwa yana haifar da 1, kuma jimlar yawan amfanin ƙasa shine kusan 47%.

Rivaroxaban wani sabon nau'in maganin ciwon zuciya ne wanda za'a iya sha kai tsaye ta baki.Yana hana kai tsaye da kunna coagulation factor Xa, yana da tabbataccen sakamako na anticoagulant, baya buƙatar ci gaba da saka idanu, kuma yana da babban aminci.Tare da aikace-aikacen asibiti na rivaroxaban, Buƙatar rivaroxaban zai ƙaru a hankali.Sunan sinadarai na rivaroxaban shine 5-chloro-N-(((5S) -2-oxo-3-[4- (3-oxo- 4-morpholinyl) phenyl)) -1,3-oxazolidine-5-yl) methyl -2-thiophenecarboxamide.A halin yanzu akwai hanyoyi guda biyu na synthetic da aka ruwaito a cikin wallafe-wallafen, kuma ana amfani da hanyoyi guda biyu A matsakaici 4- (4-aminophenyl) -3-morpholinone.Ko da yake akwai rahotanni game da kira na 4- (4-aminophenyl) -3-morpholinone a gida da waje, akwai farashi mai mahimmanci na kayan aiki.Maɗaukaki, da wuyar siye, ko buƙatun aiki na amsawa sun yi yawa, da wuya a fahimta, ba su dace da kariyar muhalli da sauran ƙarancin ba, kuma ba su cika buƙatun samar da masana'antu ba.Inganta maɓalli mai mahimmanci na rivaroxaban 4- (4-aminophenyl) - Tsarin samar da 3-morpholinone da rage farashin albarkatun kasa tabbas zai inganta haɓakawa da aikace-aikacen rivaroxaban.Babu wani rahoto kan hada-hadar rivaroxaban a kasar Sin.Muna a rivaroxaban Maɓallin tsaka-tsakin 4-- (4-aminophenyl) -3-morpholinone synthetic hanya da fasaha an yi nazarin sabbin abubuwa.Biyu bromobenzene da p-nitrobromobenzene kamar yadda aka gabatar da kayan farawa.Hanyar hanya.Mayar da hankali kan tsarin hawan keke na zoben 3-morpholinone.