Casp ungin Acetate;Caspofungin acetate;Cancidas;Caspofungin acetate [USAN:BAN:JAN];
![Casp ungin Acetate;Caspofungin acetate;Cancidas;Caspofungin acetate [USAN:BAN:JAN];Siffar Hoton](http://cdn.globalso.com/jindunchem-med/fbe17385.jpg)
Casp ungin Acetate;Caspofungin acetate;Cancidas;Caspofungin acetate [USAN:BAN:JAN];
Caspofungin Acetate Ayyukan Halittu
| Bayyana | Caspofungin Acetate magani ne na fungal wanda ba zai iya hana gasa ba tare da haɗin gwiwar 1,3-β-d glucan synthase. |
| Masu alaƙasassa | Hanyar sigina >> Anti-infective >> Fungus Yankunan bincike >> Kamuwa da cuta |
| A cikin vivobincike | Berayen da aka yi musu allura tare da caspofungin ba su da wani muhimmin canje-canje a cikin sigar motsin su ta ERG a ma'aunin vitreous na 0.41 zuwa 4.1 μM, kuma retina ɗinsu ba su da sauye-sauyen yanayi ko asarar tantanin halitta.A cikin ƙwayar vitreous na 41 μM, caspofungin ya rage girman girman igiyar igiyar ruwa, kalaman b da scotopic ƙofa na ERG, kuma ya haifar da raguwar adadin ƙwayoyin sel a cikin ganglion cell Layer [1].Carprofungin (8 mg / kg) ko amphotericin B 1 mg / kg, allurar intraperitoneal sau ɗaya a rana 30 hours bayan kamuwa da cuta na kwanaki 7 a jere, dangane da maganin kula da abin hawa, 100% tsira a ranar 28, wanda ya haifar da rana 100% adadin mace-mace 11 , bayan ƙalubalen cututtuka.Idan aka kwatanta da maganin kula da abin hawa a ranar 5, caspofungin ya rage farfadowar Candida mai yiwuwa a cikin koda da nama na kwakwalwa lokacin da nauyin sarrafawa ya kai ga kololuwar.Mice da aka yi amfani da su tare da caspofungin a kashi na 2 mg / kg ko sama da haka yana da ƙananan nauyin kwakwalwa a ranar 5 fiye da ƙwanƙwasa da aka yi da amphotericin B. Amphotericin B da maganin caspofungin sun rage nauyin fungal na koda ta 1.7 log CFU / g da 2.46 zuwa 3.64 log CFU /g, bi da bi [2]. |
| Dabbagwaji | An fara maganin rigakafin fungal sa'o'i 30 bayan ƙalubalen cutar kuma an ba da shi ta hanyar allurar intraperitoneal (ip) sau ɗaya a rana tsawon kwanaki 7.An bi da mice tare da 1, 2, 4, ko 8 mg/kg/day caspofungin, 1 mg/kg/ day amphotericin B ko abin hawa (ruwa mai tsaftataccen ruwa).An yi la'akari da ingancin samfurin ta hanyoyi uku: ta hanyar lura da yawan rayuwa na dabbobi 10 a cikin kowane rukuni na jiyya, ta hanyar lura da nauyin Candida a cikin koda da kwakwalwa na rukuni na biyu na dabbobin da aka bi da su, da kuma ta hanyar nazarin tarihin kodan.Kuma kwakwalwa.Rukuni na uku na dabbobin da aka bi da su.An lalata berayen ta hanyar CO 2 inhalation kuma an tsara su a cikin sa'o'i 30 (ikon sarrafa abin hawa kawai) kuma a ranar 5 (awanni 24 bayan kashi na 4), 8 (awanni 24 bayan kashi na ƙarshe), da 14, 21 hours Kuma histological samfurin nama.(Maganin caspofungin kawai), da 28 bayan harin. |
| Magana | [1].Mojumder DK, et al.Ƙimar ƙwayar cutar ta retinal na intravitreal caspofungin a cikin idon linzamin kwamfuta.Zuba jari Ophthalmol Vis Sci.2010 Nuwamba; 51 (11): 5796-803. [2].Flattery, Amy M. et al.Ingancin caspofungin a cikin samfurin linzamin kwamfuta na matasa na tsarin jijiya na tsakiya candidiasis.Ma'aikatan Antimicrobial da Chemotherapy (2011), 55 (7), 3491-3497. |
Abubuwan sinadarai da na zahiri na caspofungin acetate
| Wurin tafasa | 1408.1ºC a 760 mmHg |
| Tsarin kwayoyin halitta | Saukewa: C56H96N10O19 |
| Nauyin kwayoyin halitta | 1093.31000 |
| Daidaitaccen inganci | 1092.64000 |
| PSA | 412.03000 |
| LogP | 0.06150 |
| Halayen bayyanar | fari zuwa m |
| Matsin tururi | 0mmHg a 25 ° C |
| Yanayin ajiya | 20°C |
| Ruwa mai narkewa | H2O: mai soluble15mg/ml (bayani bayani) |
Caspofungin Acetate Customs
| Lambar kwastam | 293399009 |
| Bayanin Sinanci | 2933990099. Sauran mahadi heterocyclic dauke da nitrogen heteroatoms kawai.Ƙimar-Ƙara haraji: 17.0%.Yawan rangwamen haraji: 13.0%.Sharuɗɗan tsari: Babu.Farashin kuɗin ƙasa mafi fifiko: 6.5%.Janar jadawalin kuɗin fito: 20.0% |
| Abubuwan sanarwa | Sunan samfur, abun ciki na sinadarai, amfani, hexamethylene chloride, da fatan za a nuna bayyanar, 6-caprolactam, da fatan za a nuna bayyanar, ranar sa hannu |
| Takaitawa | 2933990090. heterocyclic mahadi tare da nitrogen hetero-atom(s) kawai.VAT: 17.0%.Yawan rangwamen haraji: 13.0%..Farashin MFN: 6.5%.Janar jadawalin kuɗin fito: 20.0% |
Tsarin samarwa
Caspofungin yana buƙatar shirya ta hanyar fasaha na fermentation Semi-synthetic.Ana buƙatar ɗanyen samfurin babban zobe ta hanyar fasahar fermentation, sannan ana samun matsakaicin samfurin ta hanyar rabuwa da tsarkakewa, sannan ana amfani da matsakaicin samfurin azaman kayan farawa don kammala sassan sassan gefe ta amfani da fasahar roba don samun ƙarshe. Abinda ake nufi.Saboda samfuran "fermented semi-synthetic" suna buƙatar shiga ta hanyoyin haɗin fasaha da yawa kamar su fermentation, rabuwa da tsarkakewa, haɗawa, da dai sauransu, hanyar fasaha da sarrafa siga na tsari suna da rikitarwa sosai a cikin Littafin Chemical.Bugu da ƙari, ƙa'idodin ƙa'idodi don yin rajista na caspofungin, samfuri mai ƙyalƙyali na roba, suma suna da girma sosai.Takaddun aikace-aikacen suna buƙatar farawa daga tushen fermentation, ba wai kawai don nazarin tsarin noma iri-iri ba, fasahar fermentation, da fasahar tsarkakewa, amma har ma don bincika tsarin haɗin gwiwa.Hanya, yanayi, da sarrafa ƙazanta a cikin tsari, saboda samfurin ƙarshe yana da rauni sosai, duk wani rashin kulawa zai shafe duk ƙoƙarin da ya gabata, kuma wahalar fasaha da tsada ba su da ƙima.
Daidai ne saboda manyan shingaye na fasaha da kyakkyawan yanayin gasa cewa Hengrui Caspofungin ya kiyaye sararin farashi mai kyau bayan jerin sa.
Kariyar haƙƙin mallaka ta ƙare a cikin 2014
Siyar da alluran caspofungin tasha a cibiyoyin kiwon lafiya na jama'a a China (raka'a: yuan dubu goma)
Ya zuwa yanzu, kawai magungunan magunguna na Hengrui Pharmaceuticals, Chia Tai Tianqing, Borui Pharmaceuticals, da Haisco ne aka amince da su don jeri.Huadong Medicine?
Kamfanin bincike na asali na caspofungin acetate shine Merck, kuma jerin aikace-aikacen kamfanoni na 6 suna ƙarƙashin nazari da amincewa, wato Qilu Pharmaceutical, Nanjing Yinxing Pharmaceutical, Sihuan Pharmaceutical, Osaikang Pharmaceutical, Sino-US Huadong Pharmaceutical, da Tianceuticals Biopharmaceutical.
JIN DUN Medical yaCancantar ISO kuma ya cika ka'idodin samar da GMP, ƙwararrun ƙwararrun haɗaɗɗun ƙwayoyi na cikin gida da na waje tare da ƙwararrun ƙwarewa don jagorantar R&D na kamfani.
TECHNOL OGY AMFANIN
●High Matsi Catalytic Hydrogenation.Babban Matsi na Hydrogenolysis Reaction.Maganin Cryogenic (<-78% C)
●Aromatic Heterocyclic Synthesis
●Maganar Sake Shiryawa
●Matsalar Chiral
●Heck, Suzuki,Negishi,Sonogashira .Gignard Reaction
Kayan aiki
Our Lab yana da daban-daban na gwaji da kuma gwaji kayan aiki, kamar: NMR (Bruker 400M), HPC, Chiral-HPLC, LC-MS, LC-MS/MS (API 4000) , IR, UV, GC, GC-MS, Chromatography, Microwave Synthesizer, Parallel Synthesizer, Bambance-bambancen Scanning Calorimeter (DSC), Electron Microscope...
Ƙungiyar R&D
Jindun Medical yana da rukuni na ƙwararrun ma'aikatan R&D, kuma yana ɗaukar ƙwararrun masana harhada magunguna na cikin gida da na waje don jagorantar R&D, yana sa ƙirarmu ta fi dacewa da inganci.
Mun taimaka wa manyan kamfanonin harhada magunguna na cikin gida da yawa, kamarHansoh, Hengrui da HEC Pharm.Anan zamu nuna sashinsu.
Hali na Farko na Farko:
Lambar Waya: 110351-94-5
Hali na Musamman na Biyu:
Lambar Waya: 144848-24-8
Halin Hali na Uku:
Lambar Waya: 200636-54-0
1.Keɓance Sabbin Matsakaici ko APIs.Daidai da raba shari'ar na sama, abokan ciniki suna da buƙatun takamaiman Matsakaici ko APIs, kuma ba za su iya samun samfuran da ake buƙata ba a kasuwa, sannan za mu iya taimakawa don Keɓancewa.
2.Haɓaka Tsari don Tsofaffin Kayayyaki.Ƙungiyarmu za ta taimaka don ingantawa da haɓaka irin wannan samarwa wanda hanyar amsawa ta tsufa, farashin samarwa yana da yawa, kuma ingancin ya yi ƙasa.Za mu iya samar da cikakkun takardun shaida don canja wurin fasaha da haɓaka tsari, taimakawa abokin ciniki don samar da ingantaccen aiki.
Daga maƙasudin miyagun ƙwayoyi zuwa INDs, JIN DUN Medical yana ba kumafita na R&D keɓaɓɓen tsayawa ɗaya tasha.
JIN DUN Medical ya dage kan ƙirƙirar ƙungiyar tare da mafarkai, yin samfura masu daraja, ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwaƙƙwaran, masu tsattsauran ra'ayoyi, masu tsauri, da kuma fita gabaɗaya don zama amintaccen abokin tarayya kuma abokin abokan ciniki!
