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PriceList don Babban Ingancin Antiviral Entecavir Foda CAS 142217-69-4 tare da Mafi kyawun farashi

PriceList don Babban Ingancin Antiviral Entecavir Foda CAS 142217-69-4 tare da Mafi kyawun farashi

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Tags samfurin

Har ila yau, muna gabatar da samfur ko sabis da kamfanonin haɗin gwiwar jirgi.Muna da namu naúrar masana'anta da ofishi masu samo asali.Za mu iya sauƙi samar muku da kusan kowane nau'i na kasuwanci kama da samfurin mu iri-iri na PriceList for High Quality Antiviral Entecavir Foda CAS 142217-69-4 tare da Mafi Farashin, Za mu ci gaba da ƙoƙari don ƙara kamfaninmu da samar da samfurori masu kyau tare da m farashin jeri.Ana jin daɗin duk wani tambaya ko sharhi.Ka tuna ka kama mu kyauta.
Har ila yau, muna gabatar da samfur ko sabis da kamfanonin haɗin gwiwar jirgi.Muna da namu naúrar masana'anta da ofishi masu samo asali.Zamu iya samar muku da kusan kowane nau'i na hajoji mai kama da nau'in samfuranmu donChina Entecavir da 142217-69-4, Muna maraba da abokan ciniki na gida da na ketare don ziyarci kamfaninmu da yin magana ta kasuwanci.Kamfaninmu koyaushe yana nacewa kan ka'idar "kyakkyawan inganci, farashi mai ma'ana, sabis na aji na farko".Muna shirye don gina dogon lokaci, abokantaka da haɗin kai tare da ku.

Entecavir (SQ 34676;BMS 200475) zaɓi ne kuma mai hana HBV mai inganci.A cikin sel HepG2 EC50 darajar 3.75 nM.Sabbin magungunan anti-hepatitis B da magungunan kanjamau na farko.

Entecavir sakamako

Wannan samfurin shine analog na guanine nucleoside, wanda ke da tasirin hanawa akan cutar hanta B (HBV) polymerase.Ana iya sanya shi cikin phosphorylated cikin triphosphate mai aiki, kuma rabin rayuwar triphosphate a cikin tantanin halitta shine sa'o'i 15.Ta hanyar yin gasa tare da HBV polymerase's na halitta substrate deoxyguanosine triphosphate, entecavir triphosphate na iya hana duk ayyuka uku na kwayar cutar polymerase (reverse transcriptase): (1) HBV polymerase farawa;(2) pregenomic mRNA Samuwar madaidaicin madaidaicin rubutun baya;(3) Haɗin ingantacciyar igiyar HBV DNA.Tsawon inhibitory (Ki) na entecavir triphosphate akan HBV DNA polymerase shine 0.0012μM.Entecavir triphosphate yana da tasirin hanawa mai rauni akan tantanin halitta α, β, δ DNA polymerase da mitochondrial γ DNA polymerase, tare da ƙimar Ki na 18 zuwa 160 μM.

Bayyana

Entecavir (SQ 34676;BMS 200475) zaɓi ne kuma mai tasiri HBV Inhibitor. A cikin sel HepG2 EC50 darajar 3.75 nM.

Masu alaƙasassa

Hanyar sigina >> Anti-infective >> HBV Bincike wuraren >> Kamuwa da cuta

manufa

EC50: 3.75 nM (anti-HBV, HepG2 cell)[2]

In vitrokaratu

EC50 na BMS-200475 zuwa HBV shine 3.75 nM.An shigar da shi cikin furotin na HBV, sannan an hana matakin farawa na juyar da rubutun.Ayyukan antiviral na BMS-200475 yana da ƙasa da ƙasa fiye da sauran ƙwayoyin RNA da DNA [1].Idan aka kwatanta da sauran analogues deoxyguanosine (penciclovir, ganciclovir, lobucavir da acyclovir) ko lamivudine, entecavir zai iya zama phosphorylated zuwa metabolite mai aiki.Rabin rayuwar cikin salula na Entecavir shine sa'o'i 15 [2].

A cikin vivobincike

BMS-200475 ana bi da shi ta baki kowace rana tare da kashi daga 0.02 zuwa 0.5 MG / kg nauyin jiki na tsawon watanni 1 zuwa 3, wanda zai iya rage girman ƙwayar cutar hanta ta woodchuck (WHV) a cikin katako mai ciwon daji na kullum [3].

Cellgwaji

An shirya BMS 200475 a cikin phosphate buffered saline (PBS) kuma an diluted tare da matsakaicin matsakaici mai ɗauke da 2% fetal bovine serum.Kwayoyin HepG2 2.2.15 an shuka su a kan faranti mai rufi na 12 mai kyau Biocoat collagen a yawan 5 × 10 5 sel a kowace rijiya, kuma an adana su a cikin yanayi mai rikitarwa don kwanaki 2 zuwa 3, sannan an rufe shi da 1 ml na BMS 200475 matsakaici .An yi kididdigar HBV a rana ta 10 [1].

Magana

[1].Inamo SF, et al.Gano BMS-200475 a matsayin mai ƙarfi da zaɓi mai hana cutar hepatitis B.Magungunan Antimicrob Agents Chemother.1997 Jul; 41 (7): 1444-9.[2].Rivkin A, et al.Bita na entecavir a cikin maganin ciwon hanta na kullum.Curr Med Res Ra'ayin.2005 Nov; 21 (11): 1845-57.[3].Genovesi EV, et al.Ingancin Carbocyclic 2'-deoxyguanosine nucleoside BMS-200475 a cikin samfurin woodchuck na kamuwa da cutar hanta B.Magungunan Antimicrob Agents Chemother.1998 Dec; 42 (12): 3209-18.

Halin jiki da sinadarai na Entecavir

Yawan yawa

1.8 ± 0.1 g/cm3

Wurin tafasa

734.2ºC a 760 mmHg

Wurin narkewa

249-252ºC

Tsarin kwayoyin halitta

Saukewa: C12H15N5O3

Nauyin kwayoyin halitta

277.279

Wurin walƙiya

397.9ºC

Daidaitaccen inganci

277.117493

PSA

130.05000

LogP

-0.96

Halayen bayyanar

Fari zuwa fari-fari/rawaya crystalline foda

Indexididdigar refractive

1.837

Yanayin ajiya

-20°C injin daskarewa

Entecavir Kwastam

Lambar kwastam 293399009
Bayanin Sinanci 2933990099. Sauran mahadi heterocyclic dauke da nitrogen heteroatoms kawai.Ƙimar-Ƙara haraji: 17.0%.Yawan rangwamen haraji: 13.0%.Sharuɗɗan tsari: Babu.Farashin kuɗin ƙasa mafi fifiko: 6.5%.Janar jadawalin kuɗin fito: 20.0%
Abubuwan sanarwa Sunan samfur, abun ciki na sinadarai, amfani, hexamethylene chloride, da fatan za a nuna bayyanar, 6-caprolactam, da fatan za a nuna bayyanar, ranar sa hannu
Takaitawa 2933990090. heterocyclic mahadi tare da nitrogen hetero-atom(s) kawai.VAT: 17.0%.Yawan rangwamen haraji: 13.0%..Farashin MFN: 6.5%.Janar jadawalin kuɗin fito: 20.0%

Ƙarin bayani:

Qu Qiang (PhD a fannin likitanci na asibiti, Sashen Magunguna, Asibitin Xiangya, Jami'ar Kudancin Kudancin) da Wang Ruoguang (Doctor of Medicine, postdoctoral in Biology, Changsha Ruoguang Medical Center) ya kuma rubuta cewa: a cikin tsarin entecavir, ana iya ɗaukar entecavir. shekaru da yawa ko ma shekaru 10.Fiye da shekaru.Kuma mata masu juna biyu za su iya amfani da shi, yana nuna aminci mai kyau.

Yin la'akari da waɗannan sanannun hanyoyin magunguna na ƙwayoyin cuta, Entecavir na iya samun tasirin antiviral mai faɗi, ba kawai tasiri akan HBV ba.

Har ila yau, sau da yawa muna amfani da Entecavir don magance cututtuka na numfashi na hoto a cikin asibiti, kuma tasirin yana da ban mamaki.

A halin yanzu, a cikin bincike na baya-bayan nan na sama da 500 COVID19 marasa lafiya a Hubei (wani wuri), mutum ɗaya ne kawai ya ɗauki entecavir.Lokacin rubuta magani ya kasance a farkon watan Janairu, sannan aka dakatar da maganin.

Yayin tallafawa ma'aikatan kiwon lafiya a Hubei, wasu likitocin asali, ko ƙungiyoyi masu haɗari, a halin yanzu suna amfani da Entecavir don hana COVID19, babu wani kamuwa da cuta.Mutanen da ake zargi suna shan entecavir, babu wanda ya sami ci gaba don kamuwa da cutar ta COVID19.

Matsalolin haƙƙin mallaka:

Akwai galibi matakai guda biyu, 06 tsari da tsari 89.Ƙarewar takardar shaidar don tsarin 06 ya yi da wuri (zai ƙare a 2023)!Kodayake farashin tsarin yana da ƙasa, ingancin yana da kyau, kuma ma'aikata na iya zama masu karfi, shawarwari na sirri: Don tsire-tsire masu sinadaran, yi amfani da tsarin 06 don kada ku kasance masu girman kai;ga kamfanonin harhada magunguna, kada ku yi tagumi kuma kada ku kasance masu haɗari sosai.

A shekarar 2014, Chia Tai Tianqing ya samu cinikin yuan biliyan 10 a duk shekara ta hanyar dogaro da magunguna iri-iri kamar su entecavir, wanda entecavir ya kai kashi 20%.

Tun lokacin da aka amince da entecavir don shigo da kaya a cikin 2005, fiye da kamfanonin magunguna na cikin gida 100 sun nemi rajistar samfurin;Daga cikin su, kamfanonin da aka amince da su sun hada da Jiangsu Zhengda Tianqing Pharmaceutical (kwaikwayi na farko), Hainan Zhonghe Pharmaceutical, da Fujian Guangxi Pharmaceutical Co., Ltd. Shengtang Pharmaceutical Co., Ltd. Shengtang Pharmaceutical, Jiangxi Qingfeng Pharmaceutical, Suzhou Dawnrays Pharmaceutical Pharmaceutical Shanghai, Suzhou Dawnrays Pharmaceutical Pharmaceutical Hainan. kautical, Shandong Lukang, Zhejiang Huasheng Biopharmaceutical, Changzhi Sanbao Biochemical.

Pharmaceutical, Anhui Baker Biopharmaceutical, Hunan Concord Pharmaceutical Industry, Beijing Xiehe Pharmaceutical Factory, Beijing Baiao Pharmaceutical, Xinlitai Pharmaceutical, Dongyangguang, da dai sauransu.;kara daga kwanan wata kwangila, wannan samfurin ya shiga cikin sahu na rare ayyana iri tun 2007.

Har ila yau, muna gabatar da samfur ko sabis da kamfanonin haɗin gwiwar jirgi.Muna da namu naúrar masana'anta da ofishi masu samo asali.Za mu iya sauƙi samar muku da kusan kowane nau'i na kasuwanci kama da samfurin mu iri-iri na PriceList for High Quality Antiviral Entecavir Foda CAS 142217-69-4 tare da Mafi Farashin, Za mu ci gaba da ƙoƙari don ƙara kamfaninmu da samar da samfurori masu kyau tare da m farashin jeri.Ana jin daɗin duk wani tambaya ko sharhi.Ka tuna ka kama mu kyauta.
PriceList donChina Entecavir da 142217-69-4, Muna maraba da abokan ciniki na gida da na ketare don ziyarci kamfaninmu da yin magana ta kasuwanci.Kamfaninmu koyaushe yana nacewa kan ka'idar "kyakkyawan inganci, farashi mai ma'ana, sabis na aji na farko".Muna shirye don gina dogon lokaci, abokantaka da haɗin kai tare da ku.


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