(R) -8- (3-Amino-piperidin-1-yl) -7-amma-2-ynyl-3-methyl-1- (4-methyl-quinazolin-2-ylmethyl) -3

Linagliptin Linagliptin, wanda Boehringer Ingelheim ya haɓaka, FDA ta amince da shi a ranar 2 ga Mayu, 2011. Ana amfani da shi don haɗa abinci da motsa jiki don inganta sarrafa matakan glucose na jini a cikin masu ciwon sukari na 2.Linagliptin yana inganta sarrafa glucose na jini a cikin marasa lafiya ta hanyar hana dipeptidyl peptidase-4 (DPP-4).

Incretin (Incretin) yana da tasirin haɓaka ƙwayar insulin ta ƙwayoyin sel B na pancreatic, galibi ciki har da glucose-dependent insulinotropic polypeptide (GIP) da glucagon-like polypeptide-1 (GLP-1).DDP-4 wani nau'in protease ne na serine wanda ke saman sel.Yana ɗaure da sunadaran kuma yana da yawa a cikin plasma da kyallen takarda daban-daban a cikin jiki (kamar koda, hanta, ƙananan hanji villi, ƙwayoyin endothelial, da sauransu).Linagliptin wani zaɓi ne mai hanawa DPP-4 wanda ke hana ayyukan enzyme ta hanyar juyawa zuwa DPP-4, yana jinkirta lalata GLP-1, yana haɓaka ayyukan GLP-1, kuma yana haɓaka ta hanyar dogaro da glucose na insulin. Yana rage matakin glucagon a cikin wurare dabam dabam, ta haka ne ke daidaita matakin glucose na jini na marasa lafiya masu fama da ciwon sukari na 2.

Idan aka kwatanta da sauran masu hana DPP-4, manyan fa'idodin Linagliptin sune: yana da ingantaccen amincin koda kuma yana iya rage haemoglobin glycosylated yadda ya kamata.Linagliptin ana fitar da shi a cikin najasa a cikin nau'in samfuri.Bayan gudanar da baki, fitar da koda kashi 5% ne kawai na adadin da ake gudanarwa.Ko da an yi ta ta cikin jini, kashi 30.8 ne kawai ake fitar da shi ta hanyar koda.Saboda haka, babu buƙatar marasa lafiya da ke jurewa magani.Bincika aikin hanta da koda akai-akai da daidaita kashi.Duk marasa lafiya na iya gyara kashi iri ɗaya don sauƙin sayan magani.
Halayen da aka saba yi na Linagliptin sune kamuwa da cutar numfashi, cunkoson hanci, ciwon tsoka, ciwon kai da ciwon makogwaro.