3-Amino-4-pyrazole carbosamide hemisulfate

Matsakaici don haɗuwa da allopurinol.

Yana ɗaya daga cikin jerin pyrazole da aka maye gurbin 3-amino-4.Ana iya amfani da shi azaman tsaka-tsaki don haɗa yawancin mahadi masu tasiri na pharmacologically, irin su allopurinol, ɗaya daga cikin jerin abubuwan da suka samo asali na pyrazolopyrimidine, na ƙarshe tun 1963 Tun lokacin da aka yi amfani da shi na asibiti, ya kasance babban magani don maganin gout.A halin yanzu, akwai ƙananan hanyoyin da aka sani don haɗawa

3-aminopyrazole-4-carboxamide hemisulfate a kasar Sin, yafi ta hanyar amsa malononitrile da triethyl orthoformate don shirya ethoxymethylene malononitrile, sa'an nan kuma tare da amsawar hydrazine hydrate yana haifar da 3-amino-4-cyanopyrazole, wanda a ƙarshe ya amsa tare da samar da sulfuric acid.

3-aminopyrazole-4-carboxamide hemisulfate (Chen Huiru, Xiao Guomin et al. 3-aminopyrazole- Synthesis of 4-formamide hemisulfate [J]. Chemical Industry Times, 2008, 6 (22): 39 40), jimlar yawan amfanin ƙasa. kira da wannan hanya ne game da 60% (lissafi a matsayin malononitrile), wannan hanya Ya ƙunshi wani mataki uku dauki, da matakai sun fi tsayi, da kuma reagents amfani, kamar malononitrile da ethoxymethylene malononitrile, sun fi guba da tsada.Bugu da ƙari, 3-aminopyrazole-4 da aka shirya ta wannan hanya - Formamide hemisulfate yana da launi mai wuyar cirewa kuma yana buƙatar ƙarin aiki, wanda ya fi rikitarwa.

Akwai rahotanni a cikin wallafe-wallafen kasashen waje ta yin amfani da pyridylamide hydrazone da ethoxymethylene malononitrile a matsayin albarkatun kasa don samun 3-amino-4-cyanopyrazole ta ƙari da cyclization, sa'an nan kuma amsa tare da sulfuric acid mai da hankali don samun maƙasudin manufa (Reuken G Jones. Abubuwan da aka yi na orthoesters tare da su). mahadi masu aiki methylene [J] J Am Chem Soc. 1952,74 (5): 4889 4891).Babban albarkatun da ake amfani da su a cikin wannan hanya suna da tsada, yawan abin da ake samu ba shi da yawa, kuma ribar samar da masana'antu ba ta da yawa.Dole ne ya zama da wahala.