A wannan makon, babbar mujallar ilimi ta Nature ta buga wata takarda ta bincike ta yanar gizo ta ƙungiyar Farfesa Feng Liang a Jami'ar Stanford, tana bayyana tsari da tsarin aiki na furotin ɗin jigilar jini-kwakwalwa mai suna MFSD2A.Wannan binciken yana taimakawa wajen tsara magunguna don daidaita iyawar shingen jini-kwakwalwa.
MFSD2A shine jigilar phospholipid wanda ke da alhakin ɗaukar docosahexaenoic acid zuwa cikin kwakwalwa a cikin ƙwayoyin endothelial waɗanda ke yin shingen kwakwalwar jini.Docosahexaenoic acid an fi sani da DHA, wanda ke da mahimmanci don haɓakawa da aikin kwakwalwa.Maye gurbi da ke shafar aikin MFSD2A na iya haifar da matsalar ci gaba da ake kira ciwon microcephaly.
Ikon jigilar lipid na MFSD2A kuma yana nufin cewa wannan furotin yana da alaƙa da amincin shingen kwakwalwar jini.Binciken da aka yi a baya ya gano cewa lokacin da aka rage ayyukansa, shingen kwakwalwar jini zai zube.Sabili da haka, ana ɗaukar MFSD2A azaman canjin tsari mai ban sha'awa lokacin da ya zama dole don ketare shingen kwakwalwar jini don isar da magungunan warkewa cikin kwakwalwa.
A cikin wannan binciken, ƙungiyar Farfesa Feng Liang ta yi amfani da fasahar microscopy na cryo-electron don samun babban tsari na linzamin kwamfuta na MFSD2A, yana bayyana yanki na musamman na extracellular da rami mai ɗauri.
Haɗuwa da bincike na aiki da simintin gyare-gyaren kwayoyin halitta, masu binciken sun kuma gano wuraren daurin sodium da aka kiyaye a cikin tsarin MFSD2A, suna bayyana hanyoyin shiga lipid, da kuma taimakawa wajen fahimtar dalilin da yasa takamaiman maye gurbi na MFSD2A ke haifar da ciwo na microcephaly.
Lokacin aikawa: Satumba-01-2021