8-Bromo-7-amma-2-ynyl-3-methyl-1- (4-methyl-quinazolin-2-ylmethyl) -3

Don nazarin linagliptin da ke akwai da maɓalli na tsakiya 8-bromo-7- (2-butynyl) -3,7-dihydro-3-methyl-1-[(4-methyl-2-quinazolinyl) methyl) -1H-purine- 2,6-dione (11) hanyar haɗakarwa, sami hanyar haɗin gwiwar da ta dace da samar da masana'antu.Hanya: taƙaita hanyoyi daban-daban na roba.Sakamako da ƙarshe: Hanyar 2.2 tana da tsari mai sauƙi da ƙananan farashi, wanda ya fi dacewa da samar da masana'antu.

8-bromo-3,7-dihydro-3-methyl-1H-purine-2,6-dione shine mabuɗin tsaka-tsaki a cikin haɗin magungunan hypoglycemic linagliptin.Haɗin 1 yana amfani da methyl urea da cyanoacetic acid a matsayin kayan farawa, kuma yana jurewa matakan matakai shida na condensation, cyclization, nitrosation, raguwa, cyclization, da bromine tare da yawan amfanin ƙasa na 46.3%.1HNMR ya tabbatar da tsarin duk masu tsaka-tsaki.

Ƙirƙirar yanzu tana da alaƙa da hanyar shiri mai sauƙi na linagliptin mai tsafta.Quinazoline, mabuɗin tsaka-tsakin don shirye-shiryen tukunya ɗaya na linagliptin 8 bromo 7 (2 butyne 1 tushe) 3,7 dihydro 3 methyl 1 [(4 methyl 2 quinazolinyl) methyl] 1H Purine 2,6 dione, matsakaicin ya rabu da shi. tacewa, sannan a mayar da martani da (R)3 aminopiperidine dihydrochloride don samun maganin da ke dauke da linagliptin.Bayan an sake sarrafa maganin da ke ɗauke da linagliptin, samfurin Deliraliptin mai tsabta.Shirye-shiryen maɓalli mai mahimmanci na ƙirƙira na yanzu yana ɗaukar hanyar tukunya ɗaya, wanda ya dace don aiki da inganta yawan amfanin ƙasa.Bayan an raba tsakiyar maɓalli, ana amsa shi da (R) 3 aminopiperidine dihydrochloride, don haka Samun linagliptin mai tsafta shima ya dace da samarwa da bayyana buƙatun kamfanonin harhada magunguna zuwa mafi girma.